In four studies, two 12-month studies and two six-month studies, roflumilast showed clear therapeutic potential, decreasing exacerbations and improving lung function.
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Roflumilast represents the first in a new class of agents to treat COPD and, if approved, would be the first oral anti-inflammatory maintenance treatment for the disease. Seek medical attention right away if any of these severe side effects occur:
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* Bosentan because liver problems may occur; the effectiveness of both medicines may be decreased
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